New seizure-preventing role identified for brain immune cells

Akassoglou Lab Researchers discovered in mice studies that the brain’s microglia, cells that constantly monitor surrounding neurons, keep spontaneous seizures in check by tempering neuronal hyperactivity. To read full article, click here. 

(AP Photo/David Duprey)

An Unexpected Role for the Brain’s Immune Cells

In the new study, Akassoglou and her team show that microglia (yellow) extend their branches to touch nearby neurons (blue and green), preventing these neurons from becoming overly active and causing seizures. Video by Keun-Young Kim, Gladstone Institutes. To read full article, click here.

Young Scientists Committed to Finding Treatments for Neurodegenerative Diseases

Andrew Mendiola, PhD named 2020 Berkelhammer Scholar

Unlocking the Drivers of Neuroinflammation in Neurodegenerative Disease

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Illustration of amyloid plaques on a nerverticale cell.

MS researcher gets it in gear

Andrew Mendiola, PhD featured in Momentum, the official magazine of the National MS Society

Scientists Build Map of Toxic Immune Cells Contributing to Neurodegeneration in MS

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‘Tox-seq’ atlas of immune cells identified for neurodegenerative therapies

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Toxic Cell Atlas Guides New Therapies for Neurodegeneration

October 31, 2019

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Gladstone researchers Jae Kyu Ryu, Katerina Akassoglou, and Andrew Mendiola developed a novel method to profile toxic immune cells in the brain, and used it to identify a therapeutic target for multiple sclerosis.

Tox-seq revealed subtypes of brain immune cells that produce toxic reactive oxygen in a mouse model of MS.