Members of Akassoglou Lab working on a new study for new line of drugs to potentially stimulate myelin repair in the presence of toxic blood leaks in the brain. To view the full article, click here.
Illustration by Ella Marushchenko
The Akassoglou Lab showed toxic blood leaks in the brain inhibiting remyelination with implications for the development of therapeutic strategies for neuro-repair in multiple sclerosis and other neurological diseases with blood-brain barrier disruption and myelin damage. From Petersen et al. BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis. Pp. 2291-2301.
Barancik Prize winner Katerina Akassoglou, PhD, studies links between the brain, immune system, and blood-brain barrier.
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Scientists at Akassoglou Lab identifying toxic elements that inhibit repair of damaged myelin and producing studies to find new treatments. To view full article click here.
Since 1985, the Alzheimer’s Disease Research (ADR) program has awarded nearly $140 million to support promising research in fields ranging from molecular biology to genetics to epidemiology. ADR is currently supporting 133 outstanding biomedical researcher projects.
A small team of scientists at the Akassoglou Lab is working on what could be a big breakthrough in treating dementia and other brain diseases. To read full article , click here.
Therini Bio announced raising $17 million in a financing round to speed the development of an antibody that might treat people with inflammatory conditions, such as multiple sclerosis (MS), associated with damage to blood vessels. To read full article, click here.
Gladstone researchers harness unique tools and perspectives to pave the way to more and better treatment options for epilepsy. To read full article, click here.
Network of Co-Expressed Proteins in Cerebrospinal Fluid from Patients with CNS Lymphoma . The American Journal of Pathology, Volume 191, Issue 3, P417-588.
Abnormal leaks in the blood-brain barrier have previously been linked to the severity of CNS lymphoma. However, the molecular details remain unclear. Now, the Akassoglou Lab has shown in mice that CNS B-cell lymphoma cells cluster at sites where there is a leak in the blood-brain barrier. They also found that a blood protein called fibrinogen, which normally participates in blood clotting, promotes this clustering. To read full article, click here.
Gladstone scientist Jae Kyu Ryu, PhD, (right) and his colleagues discover new links between lymphoma growth and leaks in the blood-brain barrier.
