AARP’s $60 Million Investment in Dementia Research Continues to Pay Off

hand holding test tube in front of brain scans

A small team of scientists at the Akassoglou Lab is working on what could be a big breakthrough in treating dementia and other brain diseases. To read full article , click here. 

Therini Raises $17M to Bring Antibody to Myelin-damaging Protein Into Trials

Therini Bio financing round

Therini Bio announced raising $17 million in a financing round to speed the development of an antibody that might treat people with inflammatory conditions, such as multiple sclerosis (MS), associated with damage to blood vessels. To read full article, click here.

Leading the Way to Better Treatments for People with Epilepsy


Gladstone researchers harness unique tools and perspectives to pave the way to more and better treatment options for epilepsy. To read full article, click here. 

Our image was selected for the cover of The American Journal of Pathology March 2021 Issue

Network of Co-Expressed Proteins in Cerebrospinal Fluid from Patients with CNS Lymphoma . The American Journal of Pathology, Volume 191, Issue 3, P417-588.

New Link between Lymphoma Growth and Blood-Brain Barrier Discovered

Abnormal leaks in the blood-brain barrier have previously been linked to the severity of CNS lymphoma. However, the molecular details remain unclear. Now, the Akassoglou Lab has shown in mice that CNS B-cell lymphoma cells cluster at sites where there is a leak in the blood-brain barrier. They also found that a blood protein called fibrinogen, which normally participates in blood clotting, promotes this clustering. To read full article, click here. 

Gladstone scientist Jae Kyu Ryu, PhD, (right) and his colleagues discover new links between lymphoma growth and leaks in the blood-brain barrier.

New Research Center to Tackle Brain Diseases

Katerina Akassoglou will lead the new Gladstone-UCSF Center for Neurovascular Brain Immunology, which brings together a unique combination of expertise to enable novel therapies for Alzheimer Alzheimer’s disease and multiple sclerosis. To read full article, click here. 

The Simon Family Trust Donates $2.5 Million to Biomedical Science

A generous philanthropic gift from the Simon Family Trust is supporting the creation of the new Gladstone-UCSF Center for Neurovascular Brain Immunology, which will be led by Katerina Akassoglou, PhD, senior investigator at Gladstone Institutes. The $2.5-million donation will help scientists study neurological diseases by combining basic and clinical research in vascular biology, immunology, and neuroscience. To read full article, click here. 

Photo: Simon Family

New seizure-preventing role identified for brain immune cells

Akassoglou Lab Researchers discovered in mice studies that the brain’s microglia, cells that constantly monitor surrounding neurons, keep spontaneous seizures in check by tempering neuronal hyperactivity. To read full article, click here. 

(AP Photo/David Duprey)

An Unexpected Role for the Brain’s Immune Cells

In the new study, Akassoglou and her team show that microglia (yellow) extend their branches to touch nearby neurons (blue and green), preventing these neurons from becoming overly active and causing seizures. Video by Keun-Young Kim, Gladstone Institutes. To read full article, click here.