Our image was selected for the cover of The American Journal of Pathology March 2021 Issue

Network of Co-Expressed Proteins in Cerebrospinal Fluid from Patients with CNS Lymphoma . The American Journal of Pathology, Volume 191, Issue 3, P417-588.

New Link between Lymphoma Growth and Blood-Brain Barrier Discovered

Abnormal leaks in the blood-brain barrier have previously been linked to the severity of CNS lymphoma. However, the molecular details remain unclear. Now, the Akassoglou Lab has shown in mice that CNS B-cell lymphoma cells cluster at sites where there is a leak in the blood-brain barrier. They also found that a blood protein called fibrinogen, which normally participates in blood clotting, promotes this clustering.

Gladstone scientist Jae Kyu Ryu, PhD, (right) and his colleagues discover new links between lymphoma growth and leaks in the blood-brain barrier.

New Research Center to Tackle Brain Diseases

Katerina Akassoglou will lead the new Gladstone-UCSF Center for Neurovascular Brain Immunology, which brings together a unique combination of expertise to enable novel therapies for Alzheimer Alzheimer’s disease and multiple sclerosis.

The Simon Family Trust Donates $2.5 Million to Biomedical Science

A generous philanthropic gift from the Simon Family Trust is supporting the creation of the new Gladstone-UCSF Center for Neurovascular Brain Immunology, which will be led by Katerina Akassoglou, PhD, senior investigator at Gladstone Institutes. The $2.5-million donation will help scientists study neurological diseases by combining basic and clinical research in vascular biology, immunology, and neuroscience.

Photo: Simon Family

New seizure-preventing role identified for brain immune cells

Akassoglou Lab Researchers discovered in mice studies that the brain’s microglia, cells that constantly monitor surrounding neurons, keep spontaneous seizures in check by tempering neuronal hyperactivity.

(AP Photo/David Duprey)

Young Scientists Committed to Finding Treatments for Neurodegenerative Diseases

Andrew Mendiola, PhD named 2020 Berkelhammer Scholar

Unlocking the Drivers of Neuroinflammation in Neurodegenerative Disease

Illustration of amyloid plaques on a nerverticale cell.

MS researcher gets it in gear

Andrew Mendiola, PhD featured in Momentum, the official magazine of the National MS Society