Our lab studies mechanisms of neurovascular regulation of inflammation and tissue repair. Our research focuses on identifying the molecular and cellular interface that blood proteins utilize to interact with nervous system cells and change their functions. Our ultimate goal is to target these interactions for therapeutic intervention in neurologic diseases.
Rupture of the vasculature allows the entry of blood proteins into the brain with subsequent edema formation and neuronal damage in a variety of neurologic diseases such as stroke, multiple sclerosis (MS), Alzheimer’s Disease (AD), and spinal cord injury. Our studies aim to unravel the molecular mechanisms of the CNS response to neurovascular changes with the ultimate goal of developing novel therapeutic strategies for neurologic diseases.
We integrate animal modeling, histopathology, tissue culture and biochemistry techniques, as a multifaceted experimental approach to address the biological complexity of disease and repair mechanisms. We have developed in vivo imaging tools of the mouse brain and spinal cord that enable us to monitor disease processes in real time in the living animal.Save