PUBLICATIONS
Selected Publications
- Merlini M, Akassoglou K. Alzheimer’s disease makes new blood contacts. Blood 2017, 129(18):2462-2463. doi: 10.1182/blood-2017-03-772087. Blood 2017 May 4. [PubMed] [PDF]
- Bardehle S, Rafalski VA, Akassoglou K. Finding the “ubiquitous” threads in infection and autoimmune neuroinflammation. Nat Immunol 2017, 18:7-8. doi: 10.1038/ni.3633. [PubMed] [PDF]
- Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EMC, Khakh BS, Kleinfeld D, McGavern D, Nelson SJ, Zlokovic BV. Neurovascular & Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Front Neurosci 2016, 10:46. doi: 10.3389/fnins.2016.00046. eCollection 2016. [PubMed] [PDF]
- Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12;14(2):255-68. doi: 10.1016/j.celrep.2015.12.028. Epub 2015 Dec 31. [PubMed] [PDF]
- Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod’homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat Commun, 2015 Sep 10. doi: 10.1038/ncomms9164. [PubMed] [PDF]
- Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K. Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions. Nat Neurosci, 2015. doi: 10.1038/nn.4054. [PubMed] [PDF]
- Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol, 2014. 75:303-8. [PubMed] [PDF]
- Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun, 2012. 3:1227. [PubMed] [PDF] [Movie 1] [Movie 2] [Movie 3] [Movie 4] [Movie 5] [Movie 6] [Movie 7]
- Le Moan N, Houslay DM, Christian F, Houslay MD, Akassoglou K. Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1 alpha. Mol Cell, 2011. 44:476-90. [PubMed]
- Baeten KM, Akassoglou K. Extracellular matrix and matrix receptors in blood-brain-barrier formation and stroke. Dev Neurobiology, 2011. 71:1018-39. [PubMed]
- Schachtrup C, Ryu JK, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. Fibrinogen triggers astrocyte acar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci, 2010. 30:5843-54. [PubMed] [PDF] [Supplemental]
- Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature, 2008. 453:807-11. [PubMed] [PDF] [Supplemental] [Editor’s Choice Science STKE]
- Adams RA, Schachtrup C, Davalos D, Tsigelny I, Akassoglou K. Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: Lessons from multiple sclerosis. Curr Med Chem, 2007. 14:2925-36. [PubMed]
- Schachtrup C, Lu P, Lee JK, Jones L, Sachs BD, Ju J, Zheng B, Akassoglou K. Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated transactivation of the EGF receptor. Proc Natl Acad Scie USA, 2007. 104:11814-19. [PubMed] [PDF]
- Sachs B.D., Baillie GS, McCall JR, Passino MA, Schachtrup C, Wallace DA, Dunlop AJ, MacKenzie KF, Klussmann E, Lynch MJ, Sikorski SL, Nuriel T, Tsigelny I, Zhang J, Houslay MD, Chao MV, Akassoglou K. p75 Neurotrophin Receptor Regulates Tissue Fibrosis through Inhibition of Plasminogen Activation via a PDE4/cAMP/PKA Pathway. J Cell Biol, 2007. 177:1119-32. [PubMed] [PDF] [Editor’s Choice Science STKE] [JCB In this Issue: Scarred by a Death Receptor]
- Passino MA, Adams, RA, Sikorski SL, Akassoglou K. Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR. Science, 2007. 315:1853-56. [PubMed] [PDF] [Supplemental] [Editor’s Choice Science STKE] [This Week in Science]
- Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lassmann H, Degen JL, Akassoglou K. The fibrin-derived γ377-395 peptide inhibits microglia activation and reverses relapsing paralysis in central nervous system autoimmune disease. J Exp Med, 2007. 204, 571-82. [PubMed] [PDF]
- Akassoglou K, Adams RA, Bauer J, Mercado P, Tseveleki V, Lassmann H, Probert L, Strickland S. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA, 2004. 101:6698-703. [PubMed] [PDF]
- Akassoglou K, Yu W-M, Akpinar P, Strickland S. Fibrin inhibits peripheral nerve regeneration by arresting Schwann cell differentiation. Neuron, 2002. 33: 861-75. [PubMed] [PDF] [Editor’s Choice Science STKE]
- Akassoglou K, Strickland S. Nervous system pathologies: The fibrin perspective. Biol Chem, 2002. 383:37-45. [PubMed]
- Akassoglou K, Kombrink KW, Degen JL, Strickland S. Tissue plasminogen activator-mediated fibrinolysis protects from axonal demyelination after sciatic nerve injury. J Cell Biol, 2000. 149:1157-66. [PubMed] [PDF]
- Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann H, Kollias G and Probert L. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the CNS of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol, 1998. 153:801-13. [PubMed] [PDF]
- Akassoglou K, Probert L, Kontogeorgos G and Kollias G. Astrocyte, but not neuron-specific, transmembrane TNF triggers inflammation and degeneration in the CNS of transgenic mice. J Immunol, 1997. 158:438-45. [PubMed]
Book Chapters
- Cardona AE, Ransohoff R, Akassoglou K. Microglia. In Compehensive Developmental Neuroscience. Edts:John Rubenstein and Pasko Rakic Elsevier 2013, Chapter 41, pp. 803-817.
- Davalos D & Akassoglou K. Imaging microglia in the central nervous system: Past, present and future. In Central Nervous System Diseases and Inflammation, TE Lane et al. (eds.), Springer 2008, pp. 45-57. [Full Text]
- Akassoglou K, Kassiotis G, Kollias G, Probert L. Role for TNF in CNS inflammation, demyelination and neurodegeneration studied in transgenic mice, in Neuroimmunodegeneration Edited by P. Wong, B. Lynn, LANDES Bioscience, 1998, pp. 133-149.
