PUBLICATIONS
Selected Publications
- Merlini M, Rafalski VA, Ma K, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T Jr, Acevedo RM, Cabriga B, Thomas R, Coughlin SR, Ellisman MH, Palop JJ, Akassoglou K. Microglial Gi-dependent dynamics regulate brain network hyperexcitability. Nat Neurosci. 2021 Jan;24(1):19-23. doi: 10.1038/s41593-020-00756-7. [PubMed]
- Akassoglou K. The immunology of blood: connecting the dots at the neurovascular interface. Nat Immunol. 2020 Jul;21(7):710-712. doi: 10.1038/s41590-020-0671-z. [PubMed]
- Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 May;21(5):513-524. doi: 10.1038/s41590-020-0654-0. [PubMed]
- Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M. Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, Mucke L, Nelson RB, Akassoglou K. Fibrinogen induces microglia-mediated spine elimination and cognitive impairment in an alzheimer’s disease model. Neuron 2019, 101:1099-1108. doi: 10.10.16/j.neuron.2019.01.014 [PubMed]
[Neuron Preview] [Nat Rev Neurol Research Highligh] [Sci Transl Med Editor’s Choice] [Natural History Sampling]
- Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LO, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol 2018, 19(11):1212-1223. doi: 10.1038/s41590-018-0232-x. [PubMed]
- Petersen, MA, Ryu JK, Akassoglou K. Fibrinogen in neurological diseases: mechanisms, imaging, therapeutics. Nat Rev Neurosci. 2018, 19:283-301. doi: 10.1038/nrn.2018.13. [PubMed]
- Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron, 2017. doi: 10.1016/j.neuron.2017.10.008.[PubMed] [Neuron]
- Xu T, Stewart KM, Wang X, Liu K, Xie M, Kyu Ryu J, Li K, Ma T, Wang H, Ni L, Zhu S, Cao N, Zhu D, Zhang Y, Akassoglou K, Dong C, Driggers EM, Ding S. Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. Nature, 2017. doi: 10.1038/nature23475.[PubMed] [Nature]
- Merlini M, Akassoglou K. Alzheimer’s disease makes new blood contacts. Blood, 2017. 129(18):2462-2463. doi: 10.1182/blood-2017-03-772087. [PubMed] [PDF]
- Bardehle S, Rafalski VA, Akassoglou K. Finding the “ubiquitous” threads in infection and autoimmune neuroinflammation. Nat Immunol, 2017. 18:7-8. doi: 10.1038/ni.3633. [PubMed] [PDF]
- Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EMC, Khakh BS, Kleinfeld D, McGavern D, Nelson SJ, Zlokovic BV. Neurovascular & Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Front Neurosci, 2016. 10:46. doi: 10.3389/fnins.2016.00046. eCollection 2016. [PubMed] [PDF]
- Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod’homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat Commun, 2015 Sep 10. doi: 10.1038/ncomms9164. [PubMed] [PDF]
- Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K. Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions. Nat Neurosci, 2015. doi: 10.1038/nn.4054. [PubMed] [PDF]
- Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol, 2014. 75:303-8. [PubMed] [PDF]
- Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun, 2012. 3:1227. [PubMed] [PDF] [Movie 1] [Movie 2] [Movie 3] [Movie 4] [Movie 5] [Movie 6] [Movie 7]
- Schachtrup C, Ryu JK, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. Fibrinogen triggers astrocyte acar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci, 2010. 30:5843-54. [PubMed] [PDF] [Supplemental]
- Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature, 2008. 453:807-11. [PubMed] [PDF] [Supplemental]
[Editor’s Choice Science STKE]
- Schachtrup C, Lu P, Lee JK, Jones L, Sachs BD, Ju J, Zheng B, Akassoglou K. Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated transactivation of the EGF receptor. Proc Natl Acad Scie USA, 2007. 104:11814-19. [PubMed] [PDF]
- Sachs B.D., Baillie GS, McCall JR, Passino MA, Schachtrup C, Wallace DA, Dunlop AJ, MacKenzie KF, Klussmann E, Lynch MJ, Sikorski SL, Nuriel T, Tsigelny I, Zhang J, Houslay MD, Chao MV, Akassoglou K. p75 Neurotrophin Receptor Regulates Tissue Fibrosis through Inhibition of Plasminogen Activation via a PDE4/cAMP/PKA Pathway. J Cell Biol, 2007. 177:1119-32. [PubMed] [PDF]
[Editor’s Choice Science STKE] [JCB In this Issue: Scarred by a Death Receptor]
- Passino MA, Adams, RA, Sikorski SL, Akassoglou K. Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR. Science, 2007. 315:1853-56. [PubMed] [PDF] [Supplemental]
[Editor’s Choice Science STKE] [This Week in Science]
- Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lassmann H, Degen JL, Akassoglou K. The fibrin-derived γ377-395 peptide inhibits microglia activation and reverses relapsing paralysis in central nervous system autoimmune disease. J Exp Med, 2007. 204, 571-82. [PubMed] [PDF]
- Akassoglou K, Adams RA, Bauer J, Mercado P, Tseveleki V, Lassmann H, Probert L, Strickland S. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA, 2004. 101:6698-703. [PubMed] [PDF]
- Akassoglou K, Yu W-M, Akpinar P, Strickland S. Fibrin inhibits peripheral nerve regeneration by arresting Schwann cell differentiation. Neuron, 2002. 33: 861-75. [PubMed] [PDF]
[Editor’s Choice Science STKE]
- Akassoglou K, Strickland S. Nervous system pathologies: The fibrin perspective. Biol Chem, 2002. 383:37-45. [PubMed]
- Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann H, Kollias G and Probert L. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the CNS of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol, 1998. 153:801-13. [PubMed] [PDF]
- Akassoglou K, Probert L, Kontogeorgos G and Kollias G. Astrocyte, but not neuron-specific, transmembrane TNF triggers inflammation and degeneration in the CNS of transgenic mice. J Immunol, 1997. 158:438-45. [PubMed]
Book Chapters