Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer’s disease models
Miller SR, Luxem K, Lauderdale K, Nambiar P, Honma PS, Ly KK, Bangera S, Bullock M, Shin J, Kaliss N, Qiu Y, Cai C, Shen K, Mallen KD, Yan Z, Mendiola AS, Saito T, Saido TC, Pico AR, Thomas R, Roberson ED, Akassoglou K, Bauer P, Remy S, Palop JJ. Cell Rep 2024 Oct 19; 43(11):114870 [DOI] [PubMed]

Fibrinogen inhibits sonic hedgehog signaling and impairs neonatal cerebellar development after blood-brain barrier disruption
Weaver O, Gano D, Zhou Y, Kim H, Tognatta R, Yan Z, Ryu JK, Brandt C, Basu T, Grana M, Cabriga B, Alzamora MDPS, Barkovich AJ, Akassoglou K, Petersen MA. Proc Natl Acad Sci USA 2024 Jul 30; 121(31):e2323050121 [DOI] [PubMed]

Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation
Dean T, Mendiola AS, Yan Z, Meza-Acevedo R, Cabriga B, Akassoglou K, Ryu JK. J Neuroinflammation 2024 Apr 15; 21(1):94 [DOI] [PubMed]

Fibrin drives thromboinflammation and neuropathology in COVID-19
Ryu JK, Yan Z, Montano M, Sozmen EG, Dixit K, Suryawanshi RK, Matsui Y, Helmy E, Kaushal P, Makanani SK, Deerinck TJ, Meyer-Franke A, Rios Coronado PE, Trevino TN, Shin MG, Tognatta R, Liu Y, Schuck R, Le L, Miyajima H, Mendiola AS, Arun N, Guo B, Taha TY. Nature 2024 Sep; 633(8031):905-913 [DOI] [PubMed]

Fibrin induces neurotoxic microglia gene programs in neurodegeneration
Mendiola AS, Akassoglou K. Nat Immunol 24, 1062–1063 (2023) [DOI] [PubMed]

Pioneering discovery and therapeutics at the brain-vascular-immune interface
Akassoglou K, Davalos D, Mendiola AS, Petersen MA, Ryu JK, Schachtrup C, Yan Z. Cell 2024 Oct 17;187(21):5871-5876 [DOI] [PubMed]

Fibrin drives thromboinflammation and neuropathology in COVID-19 (copy)
Ryu JK, Yan Z, Montano M, Sozmen EG, Dixit K, Suryawanshi RK, Matsui Y, Helmy E, Kaushal P, Makanani SK, Deerinck TJ, Meyer-Franke A, Rios Coronado PE, Trevino TN, Shin MG, Tognatta R, Liu Y, Schuck R, Le L, Miyajima H, Mendiola AS, Arun N, Guo B, Taha TY. Nature 2024 Sep; 633(8031):905-913 [DOI] [PubMed]

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling
Mendiola AS, Yan A, Dixit K, Johnson JR, Bouhaddou M, Meyer-Franke A, Shin M-G, Yong Y, Agrawal A, MacDonald E, Muthukumar G, Pearce C, Arun N, Cabriga B, Meza-Acevedo R, Alzamora P, Zamvil SS, Pico AR, Ryu JK, Krogan NJ, Akassoglou K. Nat Immunol 24(7): 1173–1187, PMCID: PMC10307624. doi: 10.1038/s41590-023-01522-0 [DOI] [PubMed]

BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis
Petersen MA, Tognatta R, Meyer-Franke A, Bushong EA, Mendiola AS, Yan Z, Muthusamy A, Merlini M, Meza-Acevedo R, Cabriga B, Zhou Y, Thomas R, Ryu JK, Lassmann H, Ellisman MH, Akassoglou K.. Brain 144(8):2291-2301. doi: 10.1093/brain/awab106. PMID: 34426831; PMCID: PMC8418337. [DOI] [PubMed]

Microglial G_i-dependent dynamics regulate brain network hyperexcitability
Merlini M, Rafalski VA, Ma K, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T Jr, Acevedo RM, Cabriga B, Thomas R, Coughlin SR, Ellisman MH, Palop JJ, Akassoglou K.. Nat Neurosci (1):19-23. doi: 10.1038/s41593-020-00756-7.  [PubMed]

The immunology of blood: connecting the dots at the neurovascular interface
Akassoglou K.. Nat Immunol 21(7):710-712. doi: 10.1038/s41590-020-0671-z.   [PubMed]

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation
Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K.. Nat Immunol 21(5):513-524. doi: 10.1038/s41590-020-0654-0.  [PubMed]

Fibrinogen induces microglia-mediated spine elimination and cognitive impairment in an alzheimer’s disease model
Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M. Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, Mucke L, Nelson RB, Akassoglou K.. Neuron  101:1099-1108. doi: 10.10.16/j.neuron.2019.01.014  [PubMed]
[Natural History Sampling] [Sci Transl Med Editor’s Choice] [Neuron Preview] [Nat Rev Neurol Research Highlight]

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration
Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LO, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K.. Nat Immunol 19(11):1212-1223. doi: 10.1038/s41590-018-0232-x.  [PubMed]

Fibrinogen in neurological diseases: mechanisms, imaging, therapeutics
Petersen, MA, Ryu JK, Akassoglou K.. Nat Rev Neurosci 19:283-301. doi: 10.1038/nrn.2018.13.  [PubMed]

Alzheimer’s disease makes new blood contacts
Merlini M, Akassoglou K.. Blood  129(18):2462-2463. doi: 10.1182/blood-2017-03-772087. [PDF] [PubMed]

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage
Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absint. Neuron doi: 10.1016/j.neuron.2017.10.008. [DOI] [PubMed]

Finding the “ubiquitous” threads in infection and autoimmune neuroinflammation
Bardehle S, Rafalski VA, Akassoglou K.. Nat Immunol 18:7-8. doi: 10.1038/ni.3633. 

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism
Xu T, Stewart KM, Wang X, Liu K, Xie M, Kyu Ryu J, Li K, Ma T, Wang H, Ni L, Zhu S, Cao N, Zhu D, Zhang Y, Akassoglou K, Dong C, Driggers EM, Ding S.. Nature doi: 10.1038/nature23475. [DOI] [PubMed]

Neurovascular & Immuno-Imaging: From Mechanisms to Therapies
Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EMC, Khakh BS, Kleinfeld D, McGavern D, Nelson SJ, Zlokovic BV.. Front Neurosci Proceedings of the Inaugural Symposium. 10:46. doi: 10.3389/fnins.2016.00046. eCollection 2016. [PDF] [PubMed]

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation
Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod’homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K.. Nat Commun doi: 10.1038/ncomms9164. [PDF] [PubMed]

Nuclear pore complex remodeling by p75^NTR cleavage controls TGF-β signaling and astrocyte functions
Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K.. Nat Neurosci doi: 10.1038/nn.4054. [PDF] [PubMed]

Early detection of thrombin activity in neuroinflammatory disease
Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K.. Ann Neurol 75:303-8.  [PDF] [PubMed]

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K.. Nat Commun  3:1227. [PDF] [PubMed]

Fibrinogen triggers astrocyte acar formation by promoting the availability of active TGF-beta after vascular damage
Schachtrup C, Ryu JK, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K.. J Neurosci  30:5843-54. [PDF] [Supplemental figures] [PubMed]

NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M.. Nature   453:807-11.  [PDF] [Supplemental figures] [PubMed]

Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated transactivation of the EGF receptor
Schachtrup C, Lu P, Lee JK, Jones L, Sachs BD, Ju J, Zheng B, Akassoglou K.. Proc Natl Acad Scie USA   104:11814-19.  [PDF] [PubMed]

p75 Neurotrophin Receptor Regulates Tissue Fibrosis through Inhibition of Plasminogen Activation via a PDE4/cAMP/PKA Pathway
Sachs B.D., Baillie GS, McCall JR, Passino MA, Schachtrup C, Wallace DA, Dunlop AJ, MacKenzie KF, Klussmann E, Lynch MJ, Sikorski SL, Nuriel T, Tsigelny I, Zhang J, Houslay MD, Chao MV, Akassoglou K.. J Cell Biol  177:1119-32.  [PDF] [PubMed]
[JCB In this Issue: Scarred by a Death Receptor]

Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR
Passino MA, Adams, RA, Sikorski SL, Akassoglou K.. Science  315:1853-56. [PDF] [Supplemental figures] [PubMed]

Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis
Akassoglou K, Adams RA, Bauer J, Mercado P, Tseveleki V, Lassmann H, Probert L, Strickland S.. Proc Natl Acad Sci USA  101:6698-703.  [PDF] [PubMed]

Fibrin inhibits peripheral nerve regeneration by arresting Schwann cell differentiation
Akassoglou K, Yu W-M, Akpinar P, Strickland S.. Neuron  33: 861-75.  [PDF] [PubMed]

Nervous system pathologies: The fibrin perspective
Akassoglou K, Strickland S..  Biol Chem  383:37-45. [PubMed]

Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the CNS of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy
Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann H, Kollias G and Probert L.. Am J Pathol  153:801-13. [PDF] [PubMed]

Astrocyte, but not neuron-specific, transmembrane TNF triggers inflammation and degeneration in the CNS of transgenic mice
Akassoglou K, Probert L, Kontogeorgos G and Kollias G.. J Immunol  158:438-45. [PubMed]