Abnormal leaks in the blood-brain barrier have previously been linked to the severity of CNS lymphoma. However, the molecular details remain unclear. Now, the Akassoglou Lab has shown in mice that CNS B-cell lymphoma cells cluster at sites where there is a leak in the blood-brain barrier. They also found that a blood protein called fibrinogen, which normally participates in blood clotting, promotes this clustering.
Gladstone scientist Jae Kyu Ryu, PhD, (right) and his colleagues discover new links between lymphoma growth and leaks in the blood-brain barrier.