Nature Immunology Selected Our Image For The July 2023 Volume 24 Cover
Katerina Akassoglou and colleagues provide single-cell RNA-sequencing and phosphoproteome analyses of CNS microglia and macrophages in response to blood proteins including activated complement and fibrin. Their findings point to potential therapeutic targeting of microglia activation by immune and vascular signals.
Brain Selected Our Image For The August 2021 Volume
Illustration by Ella Marushchenko
The Akassoglou Lab showed toxic blood leaks in the brain inhibiting remyelination with implications for the development of therapeutic strategies for neuro-repair in multiple sclerosis and other neurological diseases with blood-brain barrier disruption and myelin damage. From Petersen et al. BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis. Pp. 2291-2301.
AARP’s $60 Million Investment in Dementia Research Continues to Pay Off
A small team of scientists at the Akassoglou Lab is working on what could be a big breakthrough in treating dementia and other brain diseases. To read full article , click here.
New Research Center to Tackle Brain Diseases
Katerina Akassoglou will lead the new Gladstone-UCSF Center for Neurovascular Brain Immunology, which brings together a unique combination of expertise to enable novel therapies for Alzheimer Alzheimer’s disease and multiple sclerosis. To read full article, click here.
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model, Published in Neuron, Mar 2019
February 5, 2019
Gladstone scientists Katerina Akassoglou and Mario Merlini found that a blood protein destroys memory storage sites in the brain and may lead to new treatments.
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New Immunotherapy Targeting Blood-Clotting Protein Protects MS and AD, Published in Nat Immunol 2018
$4.5 Million to Study How Neurovascular Dysfunction Contributes to Neurodegeneration in Alzheimer’s Disease
October 31, 2019
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Jorge Palop (left) and Katerina Akassoglou (right) received an NIH grant to study the link between neurovascular dysfunction and cognitive decline in Alzheimer’s disease.
