Katerina Akassoglou and colleagues provide single-cell RNA-sequencing and phosphoproteome analyses of CNS microglia and macrophages in response to blood proteins including activated complement and fibrin. Their findings point to potential therapeutic targeting of microglia activation by immune and vascular signals.
The Akassoglou Lab showed toxic blood leaks in the brain inhibiting remyelination with implications for the development of therapeutic strategies for neuro-repair in multiple sclerosis and other neurological diseases with blood-brain barrier disruption and myelin damage. From Petersen et al. BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis. Pp. 2291-2301.
A small team of scientists at the Akassoglou Lab is working on what could be a big breakthrough in treating dementia and other brain diseases. To read full article , click here.
Katerina Akassoglou will lead the new Gladstone-UCSF Center for Neurovascular Brain Immunology, which brings together a unique combination of expertise to enable novel therapies for Alzheimer Alzheimer’s disease and multiple sclerosis. To read full article, click here.
February 5, 2019
Gladstone scientists Katerina Akassoglou and Mario Merlini found that a blood protein destroys memory storage sites in the brain and may lead to new treatments.
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October 15, 2018
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October 31, 2019
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November 17, 2016