Entries by Mike Pierce

Fibrin fuels thromboinflammation and brain damage in COVID-19

In an article for News-Medical.net Vijay Kumar Malesu highlights the recent study published in the journal Nature. “Uncovering the molecular interactions between fibrin and the SARS-CoV-2 spike protein, researchers pave the way for targeted therapies that could curb the devastating effects of long COVID.” Read more here.

Preventing Brain Damage in Preterm Babies

“As a neonatologist and neuroscientist, it’s frustrating that we don’t have any treatments to counteract the harmful effects of bleeding in the developing brain, even though we know it often leads to lasting problems,” says Petersen, director of the Neuro-Intensive Care Nursery at UC San Francisco (UCSF), associate professor of pediatrics at UCSF, and a […]

Discovery of How Blood Clots Harm Brain and Body in COVID-19 Points to New Therapy

In a study that reshapes what we know about COVID-19 and its most perplexing symptoms, scientists have discovered that the blood coagulation protein fibrin causes the unusual clotting and inflammation that have become hallmarks of the disease, while also suppressing the body’s ability to clear the virus. Importantly, the team also identified a new antibody […]

Katerina Akassoglou Receives 2024 Pharmacia-ASPET Award

Katerina Akassoglou, PhD, FASPET ASPET is pleased to award Dr. Katerina Akassoglou, PhD from the University of California, San Francisco, the 2024 Pharmacia-ASPET Award for Experimental Therapeutics. This award recognizes outstanding research in pharmacology and experimental therapeutics, basic laboratory or clinical research that has had, or potentially will have, a major impact on the pharmacological treatment of disease. Dr. […]

A New Therapeutic Target for Traumatic Brain Injury

The glaring absence of treatments for such a widespread condition drove a team of scientists at Gladstone Institutes to uncover, on a molecular level, how traumatic brain injuries trigger neurodegeneration—and just as importantly, how to target that process to prevent long-term damage. “We set out to address the fundamental question of exactly what happens in the […]

How Blood That Leaks into the Brain Makes Immune Cells Toxic

“Our study answers, for the first time in a comprehensive way, how blood that leaks into the brain hijacks the brain’s immune system to cause toxic effects in brain diseases,” said Akassoglou, who is also director of the Center for Neurovascular Brain Immunology at Gladstone and a professor of neurology at UC San Francisco (UCSF). […]

Revealing How Blood Triggers Brain Disease

In patients with neurological diseases like Alzheimer’s disease and multiple sclerosis, immune cells in the brain known as microglia that normally fulfill beneficial functions become harmful to neurons, leading to cognitive dysfunction and motor impairment. These harmful immune cells may also contribute to age-related cognitive decline in people without dementia. Read more here.    

Nature Immunology Selected Our Image For The July 2023 Volume 24 Cover

Katerina Akassoglou and colleagues provide single-cell RNA-sequencing and phosphoproteome analyses of CNS microglia and macrophages in response to blood proteins including activated complement and fibrin. Their findings point to potential therapeutic targeting of microglia activation by immune and vascular signals.